Thionyl Chloride → 4-(1H-1,2,4-Triazol-1-yl)benzoyl chloride

HRID 1808875ノート

反応式

HRID 1808875 の反応式
[N:1]1([C:6]2[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.S(Cl)([Cl:17])=O>>[N:1]1([C:6]2[CH:14]=[CH:13][C:9]([C:10]([Cl:17])=[O:11])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 7365314-(1H-1,2,4-Triazol-1-yl)benzoic acid

生成物 1

HCID 450819094-(1H-1,2,4-Triazol-1-yl)benzoyl chloride収率 100%

実験手順

4-(1H-1,2,4-triazol-1-yl)benzoic acid (100 mg, 0.529 mmol) in sulfurous dichloride (2 ml) was refluxed at 110° C. for 2 h. After the excess SOCl2 was removed, the residue was dried in vacuo to give 4-(1H-1,2,4-triazol-1-yl)benzoyl chloride (110 mg, 0.529 mmol, 100% yield) as a white solid which was used in subsequent reactions without further purification.

後処理

  1. customAfter the excess SOCl2 was removed
  2. customthe residue was dried in vacuo

出典と根拠

ORDレコード
ord-abd5d89a47484141a88643f312bcc924
出典データセット
uspto-grants-2013_01
特許番号
US08362004B2

反応ノート

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