Trifluoroacetic acid → Methyl 2-amino-5-chloro-4-(piperazin-1-yl)benzoate
反応式
C(OC([NH:8][C:9]1[C:10]([C:29]([O:31][CH3:32])=[O:30])=[CH:11][C:12]([Cl:28])=[C:13]([N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH:14]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1[CH:14]=[C:13]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:12]([Cl:28])=[CH:11][C:10]=1[C:29]([O:31][CH3:32])=[O:30]参加物
4
実験手順
A solution of tert-butyl 4-(5-(tert-butoxycarbonylamino)-2-chloro-4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate (130 mg, 0.277 mmol) and TFA (0.4 mL, 5.19 mmol) in DCM (0.4 mL) was stirred at RT for one hour. Solvent was evaporated in vacuo to give 89 mg of methyl 2-amino-5-chloro-4-(piperazin-1-yl)benzoate. HPLC/MS showed MS (ESI+) (m/z) 270 ([M+H]+).