tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate → (S)-2-(1,8-Naphthyridin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester

HRID 18090

反応式

HRID 18090 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylateHCID 51528382-Chloro-1,8-naphthyridine

生成物 1

HCID 86626012(S)-2-(1,8-Naphthyridin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester収率 70.8%

実験手順

The title compound (0.28 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (0.35 g) and 2-chloro-1,8-naphthyridine (0.19 g) according to the method of D30.

出典と根拠

ORDレコード
ord-f81a3654b4404a418e11bbcfcd345352
出典データセット
uspto-grants-2010_06
特許番号
US07741329B2

関連ノート

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