Sodium Hydroxide → 2-Bromo-5-ethylthiophene-3-carboxylic acid

HRID 1809081ノート

反応式

HRID 1809081 の反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[Br:13])=[O:5])C.[OH-].[Na+]>O>[Br:13][C:7]1[S:8][C:9]([CH2:11][CH3:12])=[CH:10][C:6]=1[C:4]([OH:5])=[O:3]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 12588560Ethyl2-bromo-5-ethylthiophene-3-carboxylate

生成物 1

HCID 595425222-Bromo-5-ethylthiophene-3-carboxylic acid収率 70.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
140 °C

実験手順

2-Bromo-5-ethyl-thiophene-3-carboxylic acid ethyl ester (0.7 g, 2.65 mmol) was dissolved in IMS (4 mL) and aqueous sodium hydroxide (1 M, 6 mL) was added. The reaction was heated to 140° C. using microwave irradiation for 10 minutes. Water (5 mL) was added and the white precipitate formed was isolated by filtration, washed with water and then dried under vacuum to give the title compound (0.44 g). 1H NMR (400 MHz, CHCl3-d): δ 7.1 (s, 1H), 2.7 (q, 2H), 1.25 (t, 3H).

後処理

  1. custommicrowave irradiation for 10 minutes
  2. customthe white precipitate formed
  3. customwas isolated by filtration
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-b8fa958165c549af9c83f0f96aa5bf86
出典データセット
uspto-grants-2013_01
特許番号
US08362008B2

反応ノート

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