Bromoacetone → 1,6-Dimethyl-8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-1-ium bromide salt
反応式
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([NH2:9])=[O:8].[Br:10][CH2:11][C:12](=O)[CH3:13]>C(#N)C>[Br-:10].[CH3:1][N+:2]1[CH:6]=[CH:5][N:4]2[CH:11]=[C:12]([CH3:13])[NH:9][C:7](=[O:8])[C:3]=12参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 1-Methyl-1H-imidazole-2-carboxylic acid amide (3.0 g, 14.3 mmol), bromoacetone (2.36 g, 17.2 mmol) and acetonitrile (40 mL) is stirred overnight at 80° C. The solid formed is filtered and washed with acetonitrile to give 1,6-dimethyl-8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-1-ium bromide salt (4.3 g, 86%).
後処理
- customThe solid formed
- filtrationis filtered
- washwashed with acetonitrile
出典と根拠
- ORDレコード
- ord-d10cd3f347774ff1a7c89d2309ce0c33
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362018B2
反応ノート
読み込み中…