N-bromobutanimide → 3,6,8-Tribromoimidazo[1,2-a]pyrazine

HRID 1809198ノート

反応式

HRID 1809198 の反応式
[Br:1]N1C(=O)CCC1=O.[Br:9][C:10]1[N:11]=[C:12]([Br:19])[C:13]2[N:14]([CH:16]=[CH:17][N:18]=2)[CH:15]=1>ClCCl>[Br:1][C:16]1[N:14]2[CH:15]=[C:10]([Br:9])[N:11]=[C:12]([Br:19])[C:13]2=[N:18][CH:17]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

生成物 1

HCID 142076223,6,8-Tribromoimidazo[1,2-a]pyrazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

N-bromosuccinimide (1.81 g, 10.15 mmol) was added to a solution of 6,8-Dibromo-imidazo[1,2-a]pyrazine (2.0 g, 10.15 mmol) in dichloromethane (40 ml). The reaction was stirred at room temperature over night then diluted with dichloromethane (100 ml) and washed with saturated aqueous sodium hydrogen carbonate (2×50 ml) and brine (50 ml). The organic layer was dried (MgSO4), filtered and concentrated in vaccuo. The product, 3,6,8-Tribromo-imidazo[1,2-a]pyrazine was obtained as a pink solid (2.77 g), sufficiently pure to be used in subsequent reactions.

後処理

  1. washwashed with saturated aqueous sodium hydrogen carbonate (2×50 ml) and brine (50 ml)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vaccuo

出典と根拠

ORDレコード
ord-0fb4b0376bbf47478e875a3846773a01
出典データセット
uspto-grants-2013_01
特許番号
US08362018B2

反応ノート

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