Ammonium Hydroxide → 3-Cyanobenzene-1-sulfonamide

HRID 1809201

反応式

HRID 1809201 の反応式
[NH4+:1].[OH-].[C:3]([C:5]1[CH:6]=[C:7]([S:11](Cl)(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1)#[N:4]>C(#N)C>[C:3]([C:5]1[CH:6]=[C:7]([S:11]([NH2:1])(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1)#[N:4]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 28013603-Cyanobenzene-1-sulfonyl chloride

生成物 1

HCID 28087183-Cyanobenzene-1-sulfonamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

NH4OH (22 mL, excess) can be added to a solution of 3-cyanobenzene-1-sulfonyl chloride (1.0 g, 4.97 mmol) in acetonitrile (22 mL) and the reaction stirred overnight at r.t. The reaction can be concentrated and the solid obtained washed with water to give 500 mg of product. The water phase can be extracted with AcOEt, dried with MgSO4 anh, filtered and evaporated to give 400 mg of product that can be combined with the solid obtained before (0.90 g, 99%).

後処理

  1. customThe reaction
  2. concentrationcan be concentrated
  3. customthe solid obtained
  4. washwashed with water

出典と根拠

ORDレコード
ord-677cb9023bfe48a5bb62101c1c42c633
出典データセット
uspto-grants-2013_01
特許番号
US08362018B2

関連ノート

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