Methanol → 1-(5-Bromo-3-(phenylthio)pyridin-2-yl)thiourea

HRID 1809555ノート

反応式

HRID 1809555 の反応式
C([NH:9][C:10]([NH:12][C:13]1[C:18]([S:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:17][C:16]([Br:26])=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.CO.[OH-].[Na+]>O>[Br:26][C:16]1[CH:17]=[C:18]([S:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=1

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 866314871-Benzoyl-3-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea

生成物 1

HCID 866314861-(5-Bromo-3-(phenylthio)pyridin-2-yl)thiourea収率 96.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-Benzoyl-3-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea (25.7 g, 57.8 mmol) and MeOH (250 mL). Sodium hydroxide (38.6 mL, 116 mmol) was added and stirred at ambient temperature for 8 hours. The reaction was diluted with water (250 mL), filtered and washed with water. The precipitate was dried in vacuum oven to afford the title compound (19.0 g, 96.5% yield).

後処理

  1. filtrationfiltered
  2. washwashed with water
  3. customThe precipitate was dried in vacuum oven

出典と根拠

ORDレコード
ord-0985b548f9f04cddbc9ee16d9ae2c4c5
出典データセット
uspto-grants-2013_01
特許番号
US08362037B2

反応ノート

読み込み中…