Hydrazine → HCID 178478327、化合物
反応式
[Br:1][C:2]1[N:7]=[C:6]([C:8]([C:10]2[C:11](Cl)=[N:12][C:13]([Cl:16])=[N:14][CH:15]=2)=O)[CH:5]=[CH:4][CH:3]=1.[NH2:18][NH2:19]>C1COCC1>[Br:1][C:2]1[N:7]=[C:6]([C:8]2[C:10]3[C:11](=[N:12][C:13]([Cl:16])=[N:14][CH:15]=3)[NH:19][N:18]=2)[CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a stirred solution of (6-bromo-pyridin-2-yl)-(2,4-dichloro-pyrimidin-5-yl)-methanone (from Example 29 supra) (2.42 g, 7.54 mmol) in THF (30 mL) was added hydrazine (454 mg, 9.08 mmol) and the mixture was stirred for 30 minutes at room temperature and then at 50° C. for 1 hour. The solvent was then removed and the solid was washed with water and dried to give crude 3-(6-bromo-pyridin-2-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine as a yellow solid. (Yield 1.7 g, crude).
後処理
- waitat 50° C. for 1 hour
- customThe solvent was then removed
- washthe solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-1e3d297cf3f3499da7665a2bdce51aec
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362023B2
反応ノート
読み込み中…