Diisopropylethylamine → 2-[(5-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester

HRID 18097

反応式

HRID 18097 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][N:18]=1.C(N(C(C)C)CC)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH:15][C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 3

HCID 81531DiisopropylethylamineHCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylateHCID 51520946-Chloro-3-pyridinecarbonitrile

生成物 1

HCID 865936772-[(5-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester収率 52.3%

実験手順

The title compound (1.54 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (2.0 g) and 2-chloro-5-cyanopyridine (1.29 g) in the presence of diisopropylethylamine (1.21 g) according to the method of D28.

出典と根拠

ORDレコード
ord-224fddf5b8804ef89fdab478bc0ff4ed
出典データセット
uspto-grants-2010_06
特許番号
US07741329B2

関連ノート

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