Sodium Hydroxide → 2-(3-Bromo-5-chlorophenyl)acetic acid

HRID 1810441ノート

反応式

HRID 1810441 の反応式
C[O:2][C:3](=[O:17])[CH:4]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Br:16])[CH:10]=1)C(OC)=O.[OH-].[Na+]>CO>[Br:16][C:11]1[CH:10]=[C:9]([CH2:4][C:3]([OH:17])=[O:2])[CH:14]=[C:13]([Cl:15])[CH:12]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 574588062-(3-Bromo-5-chloro-phenyl)-malonic acid dimethyl ester

生成物 1

HCID 153652222-(3-Bromo-5-chlorophenyl)acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(3-Bromo-5-chloro-phenyl)-malonic acid dimethyl ester (19 g, 59 mmol) in MeOH (500 mL) was treated with 1N aqueous NaOH (237 mL, 237 mmol) at 50° C. for 1.5 hours. The mixture was concentrated, and the residue was acidified and extracted twice with EtOAc. The combined organic layers were dried, filtered, and concentrated to give the title compound.

後処理

  1. concentrationThe mixture was concentrated
  2. extractionextracted twice with EtOAc
  3. customThe combined organic layers were dried
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-41b759f1484f40c1a41284429219fd41
出典データセット
uspto-grants-2013_01
特許番号
US08362044B2

反応ノート

読み込み中…