N,N-Dimethylpropargylamine → methyl (E)-[4-[3-[4-[3-(dimethylamino)propynyl)-phenyl]-3-(4-fluorophenyl)allyloxy]-2-methylphenoxy]acetate

Methyl (Z)-[4-[3-(4-Fluorophenyl)-3-(4-iodophenyl)allyloxy]-2-methylphenoxy]acetate (400 mg, 0.75 mmol; example 10 was dissolved in a mixture of anhydrous tetrahydrofuran (10 mL) and anhydrous triethylamine (20 mL). The solution was degassed and a solution of N,N-dimethylpropargylamine (125 mg, 1.50 mmol) in anhydrous tetrahydrofuran (2 mL) was added under inert atmosphere. The resulting solution was degassed once more, copper(I) iodide (23 mg, 0.12 mmol) and tetrakis(triphenylphosphine)palladium (70 mg, 0.06 mmol) were added and the mixture was degassed again. The reaction mixture was stirred at ambient temperature overnight and the resulting suspension was filtered through a paddle of silica gel. Silica gel was washed thoroughly with ethyl acetate; the filtrate was evaporated in vacuo and the residue was dissolved in dichloromethane (50 mL). The solution was washed with water (2×30 mL) and brine (2×30 mL), dried over anhydrous magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography (silica gel Fluka 60, dichloromethane/methanol 99:1) yielding methyl (E)-[4-[3-[4-[3-(dimethylamino)propynyl)-phenyl]-3-(4-fluorophenyl)allyloxy]-2-methylphenoxy]acetate as yellow oil.

1. customThe solution was degassed
2. customThe resulting solution was degassed once more
3. customthe mixture was degassed again
4. filtrationthe resulting suspension was filtered through a paddle of silica gel
5. washSilica gel was washed thoroughly with ethyl acetate
6. customthe filtrate was evaporated in vacuo
7. dissolutionthe residue was dissolved in dichloromethane (50 mL)
8. washThe solution was washed with water (2×30 mL) and brine (2×30 mL)
9. dry with materialdried over anhydrous magnesium sulfate
10. customevaporated in vacuo
11. customThe residue was purified by column chromatography (silica gel Fluka 60, dichloromethane/methanol 99:1)

ORDレコード

ord-919fcf974bc34c309867b0f9716fcacb

出典データセット

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08362016B2