HCID 57516330、化合物 → 5-Fluoro-6-methylpyridin-3-amine
反応式
C(OC(=O)[NH:10][C:11]1[CH:12]=[N:13][C:14]([CH3:18])=[C:15]([F:17])[CH:16]=1)C1C=CC=CC=1>[Pd]>[F:17][C:15]1[CH:16]=[C:11]([NH2:10])[CH:12]=[N:13][C:14]=1[CH3:18]参加物
3
実験手順
A flask is charged with (5-fluoro-6-methyl-pyridin-3-yl)-carbamic acid benzyl ester (0.20 g, 0.23 mmol) and 10% Pd/C (0.09 g, 0.08 mmol). The atmosphere is evacuated and refilled with Ar three times. To this mixture is added MeOH (10 mL). The reaction mixture is placed under an atmosphere of H2 and stirred at room temperature for 1 h. The mixture is filtered through a syringe filter and concentrated under reduced pressure to provide 5-fluoro-6-methyl-pyridin-3-ylamine as a solid.
後処理
- customThe atmosphere is evacuated
- additionrefilled with Ar three times
- additionTo this mixture is added MeOH (10 mL)
- filtrationThe mixture is filtered through a syringe
- filtrationfilter
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-35f336de08814778bc067eba02c18074
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362249B2
反応ノート
読み込み中…