Hydrochloric Acid → 2-Amino-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester hydrochloride
反応式
[CH2:1]([O:3][C:4](=[O:14])[C:5](=[N:12]O)[C:6](=[O:11])[C:7]([F:10])([F:9])[F:8])[CH3:2].[ClH:15].[H][H]>C(O)C.[Pd]>[ClH:15].[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH2:12])[C:6](=[O:11])[C:7]([F:8])([F:9])[F:10])[CH3:2]参加物
6
実験手順
A stirred solution of 4,4,4-trifluoro-2-hydroxyimino-3-oxo-butyric acid ethyl ester (55 g, 0.258 mol) in ethanol (140 ml) was added with palladium on activated carbon and 4N hydrochloric acid (90 ml) accordingly. The reaction mixture was stirred in a Parr shaker under 0.3 MPa of hydrogen at room temperature for 2.5 hours. The reaction mixture was filtered, the filtrate was concentrated to give 2-amino-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester hydrochloride (37.56 g, 61.8%) as a yellow solid.
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-13ea8f9b05724ef28b4f2cfa71be9584
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362251B2
反応ノート
読み込み中…