2,8,9-Triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo(3.3.3)undecane → Isopropyl 4-(6-(6-cyano-4-methylpyridin-3-ylamino)-5-methoxypyrimidin-4-yloxy)piperidine-1-carboxylate

反応式

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[C:3]=1[O:21][CH3:22].[NH2:23][C:24]1[C:25]([CH3:32])=[CH:26][C:27]([C:30]#[N:31])=[N:28][CH:29]=1.C(N1CCN2CCN(CC(C)C)P1N(CC(C)C)CC2)C(C)C.O(C(C)(C)C)[Na]>O1CCOCC1.CC([O-])=O.CC([O-])=O.[Pd+2].O>[C:30]([C:27]1[N:28]=[CH:29][C:24]([NH:23][C:2]2[N:7]=[CH:6][N:5]=[C:4]([O:8][CH:9]3[CH2:14][CH2:13][N:12]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]3)[C:3]=2[O:21][CH3:22])=[C:25]([CH3:32])[CH:26]=1)#[N:31]