m-Chloroperbenzoic acid → N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine

HRID 1811907ノート

反応式

HRID 1811907 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([NH:14][C:15]3[C:16]4[CH:17]=[N:18][NH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)=[N:10][CH:11]=[CH:12][N:13]=2)[CH:5]=[C:4]([S:24][CH3:25])[N:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:31]>O1CCOCC1>[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([NH:14][C:15]3[C:16]4[CH:17]=[N:18][NH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)=[N:10][CH:11]=[CH:12][N:13]=2)[CH:5]=[C:4]([S:24]([CH3:25])=[O:31])[N:3]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 66612118N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine

生成物 1

HCID 68516415N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine (20 mg, 0.057 mmol) and 3-chloroperoxybenzoic acid (14.82 mg, 0.086 mmol, Aldrich, St. Louis, Mo.—77%) in dioxane (1 mL) was stirred at room temperature for 2 h. LCMS showed no starting material left. The reaction mixture was used for the next step of reaction without purification.

後処理

  1. waitleft
  2. customThe reaction mixture was used for the next step of reaction without purification

出典と根拠

ORDレコード
ord-98f03ac6125546458dbe53f5b07de58b
出典データセット
uspto-grants-2013_01
特許番号
US08362241B2

反応ノート

読み込み中…