HCID 22505093、化合物 → HCID 22505002、化合物

HRID 1814037ノート

反応式

HRID 1814037 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1.[H][H]>[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1

参加物

5

反応物 2

HCID 22505093HCID 22505093、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 22505002HCID 22505002、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

10% Palladium on carbon (0.02 g) was added to 3-(2,6-difluoro-4-nitro-phenyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (0.2 g, 0.83 mmol) dissolved in ethyl acetate (8.0 mL). The flask was charged with hydrogen gas and the mixture was stirred at room temperature for 3 h. The reaction mixture was filtered through celite and the solvent removed to get the title compound which was used directly in the next reaction.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent removed

出典と根拠

ORDレコード
ord-a86c43f291124a21a6ab0c32345eab09
出典データセット
uspto-grants-2005_04
特許番号
US06875784B2

反応ノート

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