Bromoform → 4-Bromo-2-[[(2,3-difluorophenyl)methyl]thio]-6(trifluoromethyl)-7(8H)-pteridinone

HRID 1814268ノート

反応式

HRID 1814268 の反応式

N[C:2]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8](=[O:16])[NH:7][C:6]=2[N:5]=[C:4]([S:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=2[F:26])[N:3]=1.C(Br)(Br)[Br:28]>>[Br:28][C:2]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8](=[O:16])[NH:7][C:6]=2[N:5]=[C:4]([S:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=2[F:26])[N:3]=1

参加物

3

反応物 2

HCID 5558Bromoform

HCID 225060194-Amino-2-[[(2,3-difluorophenyl)methyl]thio]-6-(trifluoromethyl)-7(8H)-pteridinone

生成物 1

HCID 225059584-Bromo-2-[[(2,3-difluorophenyl)methyl]thio]-6(trifluoromethyl)-7(8H)-pteridinone

実験手順

The sub-titled compound was prepared from the product of example 37, step (a) (1.5 g) and bromoform (30 ml) using the method of Example 3, step (b).

出典と根拠

ORDレコード: ord-291ff8ef0b574a30973a676395e3cbae
出典データセット: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06875868B2

反応ノート

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