Dimethylamine → N,N-Dimethyl 3-nitrobenzenesulfonamide

HRID 1814645

反応式

HRID 1814645 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([S:10](Cl)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:14][NH:15][CH3:16]>C1COCC1>[CH3:14][N:15]([CH3:16])[S:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:12])=[O:11]

参加物

4

反応物 2

HCID 674DimethylamineHCID 84763-Nitrobenzenesulfonyl chloride

生成物 1

HCID 224495N,N-Dimethyl 3-nitrobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

3-Nitrobenzenesulfonyl chloride (22.8 mmol, 5.05 g) was dissolved in dry THF (50 mL). Dimethylamine in THF (2M, 34 mL) was added and the mixture was refluxed for 2 hours. Upon cooling, the mixture was filtered and the filtrate was evaporated in vacuo. The residue was dissolved in ethyl acetate (250 mL), washed with water (3×50 mL) and dried over MgSO4. Evaporation of the solvent afforded the title compound.

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureUpon cooling
  3. filtrationthe mixture was filtered
  4. customthe filtrate was evaporated in vacuo
  5. dissolutionThe residue was dissolved in ethyl acetate (250 mL)
  6. washwashed with water (3×50 mL)
  7. dry with materialdried over MgSO4
  8. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-89cc37bfb4614153853c214b9f65ea8c
出典データセット
uspto-grants-2005_04
特許番号
US06875760B2

関連ノート

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