Potassium trimethylsilanolate → 3-{3-(4-tert-Butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid

HRID 1814694

反応式

HRID 1814694 の反応式
C[O:2][C:3](=[O:39])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]([N:13]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([CH3:38])([CH3:37])[CH3:36])=[CH:31][CH:30]=2)[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:28])[NH:22][C:23]3[N:24]=[N:25][NH:26][N:27]=3)=[CH:17][CH:16]=2)=[O:12])[CH:5]=1.C[Si](C)(C)[O-].[K+]>C1COCC1>[C:35]([C:32]1[CH:31]=[CH:30][C:29]([N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:28])[NH:22][C:23]3[N:24]=[N:25][NH:26][N:27]=3)=[CH:17][CH:16]=2)[C:11](=[O:12])[NH:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:39])=[O:2])=[CH:34][CH:33]=1)([CH3:38])([CH3:36])[CH3:37]

参加物

4

反応物 2

HCID 23668039Potassium trimethylsilanolateHCID 538709223-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester

生成物 1

HCID 225019653-{3-(4-tert-Butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

To the above resin bound 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester was added a solution of potassium trimethylsilanolate in THF (1M, 5 mL). The mixture was shaken 4 hours at 25° C., filtered and allowed to react with a solution of acetic acid in THF (20%, 5 mL) at 25° C. overnight. Filtration followed by washing of the resin with dichloromethane (2×10 mL) afforded the resin bound title compound.

後処理

  1. filtrationfiltered
  2. customto react with a solution of acetic acid in THF (20%, 5 mL) at 25° C. overnight
  3. filtrationFiltration
  4. washby washing of the resin with dichloromethane (2×10 mL)
  5. customafforded the resin

出典と根拠

ORDレコード
ord-c3a8b73efd144a8f83ce6fc5f30ab49a
出典データセット
uspto-grants-2005_04
特許番号
US06875760B2

関連ノート

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