Allyl bromide → 5-(Allyloxy)-2-ethoxybenzonitrile

HRID 1814827ノート

反応式

HRID 1814827 の反応式
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:5]=1[C:6]#[N:7])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[CH:20]=[CH2:21]>CC(C)=O>[CH2:21]([O:12][C:9]1[CH:10]=[CH:11][C:4]([O:3][CH2:1][CH3:2])=[C:5]([CH:8]=1)[C:6]#[N:7])[CH:20]=[CH2:19]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 219731772-Ethoxy-5-hydroxybenzonitrile

生成物 1

HCID 219731885-(Allyloxy)-2-ethoxybenzonitrile

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

25 g of 2-ethoxy-5-hydroxybenzonitrile (153.2 mmol) (example 36A) and potassium carbonate (63.52 g, 459.6 mmol) are initially charged in 750 ml of acetone. 19.9 ml of allyl bromide (229.8 mmol) are added, and the mixture is stirred under reflux overnight. The mixture is filtered off and concentrated giving a mobile orange oil.

後処理

  1. temperatureunder reflux overnight
  2. filtrationThe mixture is filtered off
  3. concentrationconcentrated
  4. customgiving a mobile orange oil

出典と根拠

ORDレコード
ord-4ebb451c2deb46b0b5deb7c3a7096d21
出典データセット
uspto-grants-2005_04
特許番号
US06878708B2

反応ノート

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