4-Fluorobenzenesulfonyl isocyanate → 1-{3-(7-Cyclopentyl-5-methyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]-triazin-2-yl)-4-propoxyphenyl}-3-(4-fluorophenylsulfonyl)-urea

HRID 1814847ノート

反応式

HRID 1814847 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH2:26][CH3:27])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[F:28][C:29]1[CH:34]=[CH:33][C:32]([S:35]([N:38]=[C:39]=[O:40])(=[O:37])=[O:36])=[CH:31][CH:30]=1>O1CCCC1>[CH:18]1([C:17]2[N:10]3[C:11]([C:12](=[O:14])[NH:13][C:8]([C:6]4[CH:7]=[C:2]([NH:1][C:39]([NH:38][S:35]([C:32]5[CH:33]=[CH:34][C:29]([F:28])=[CH:30][CH:31]=5)(=[O:36])=[O:37])=[O:40])[CH:3]=[CH:4][C:5]=4[O:24][CH2:25][CH2:26][CH3:27])=[N:9]3)=[C:15]([CH3:23])[N:16]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

4

反応物 2

HCID 27333744-Fluorobenzenesulfonyl isocyanateHCID 1356049252-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

生成物 1

HCID 1356049541-{3-(7-Cyclopentyl-5-methyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]-triazin-2-yl)-4-propoxyphenyl}-3-(4-fluorophenylsulfonyl)-urea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The preparation is carried out analogously to the procedure of example 54 using 150 mg (0.408 mmol) of the amino compound from example 44A and 411 mg (2.04 mmol) of 4-fluorobenzenesulfonyl isocyanate in 12 ml of tetrahydrofuran, which are reacted overnight.

後処理

  1. customare reacted overnight

出典と根拠

ORDレコード
ord-3639cad215a948be9cb779ef67db7bac
出典データセット
uspto-grants-2005_04
特許番号
US06878708B2

反応ノート

読み込み中…