Hydrochloric Acid → HCID 68984012、化合物

HRID 1815505ノート

反応式

HRID 1815505 の反応式
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:7]=[CH:6][C:3]=1[CH:4]=O.C(O)(=O)[CH2:21][C:22]([OH:24])=[O:23].N1CCCCC1.Cl>N1C=CC=CC=1>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:7]=[CH:6][C:3]=1[CH:4]=[CH:21][C:22]([OH:24])=[O:23]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 11088283HCID 11088283、化合物

生成物 1

HCID 68984012HCID 68984012、化合物収率 75.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 2,3-dichloro-4-(2-methoxyphenylthio)-benzaldehyde (2.03 g), 1.44 g malonic acid, 5 mL pyridine, and 0.100 g piperidine was heated to 115 degrees for 1.5 hours. The mixture was cooled, and ice and HCl were added. The resulting solid was: filtered, washed with water and dissolved in tetrahydrofuran. This solution was dried over sodium sulfate, the solvent removed and ether added to give 1.733 g of product, m.p. 187-188 C.

後処理

  1. temperaturewas heated to 115 degrees for 1.5 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. washwashed with water
  5. dissolutiondissolved in tetrahydrofuran
  6. dry with materialThis solution was dried over sodium sulfate
  7. customthe solvent removed
  8. additionether added

出典と根拠

ORDレコード
ord-e7c4077b4bc948b6840d079a7747a91a
出典データセット
uspto-grants-2005_04
特許番号
US06878700B1

反応ノート

読み込み中…