3-Methoxyphenol → HCID 10060488、化合物

HRID 1815793ノート

反応式

HRID 1815793 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[OH2:10].[C:11]1(C)C=[CH:15][C:14](S(O)(=O)=O)=[CH:13][CH:12]=1>O1C=CCCC1.C(OCC)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH:15]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 90073-MethoxyphenolHCID 521998p-Toluenesulfonic acid monohydrate

生成物 1

HCID 10060488HCID 10060488、化合物収率 24,786.6%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 80803,4-dihydro-2H-pyran溶媒2 回

実験手順

A solution of 22 gm (177.4 mMol) 3-methoxyphenol in 30 mL dihydropyran was added dropwise to a solution of 100 mg (0.525 mMol) p-toluenesulfonic acid monohydrate in 10 mL dihydropyran while cooling in an ice/water bath. After stirring for 1 hour the reaction mixture was diluted with 300 mL diethyl ether and then washed sequentially with 100 mL 0.1 N sodium hydroxide and 100 mL saturated aqueous sodium chloride. The remaining organic phase was dried over magnesium sulfate and concentrated under reduced pressure. The resulting oil was distilled. The fraction distilling at 110-130° C. was collected and then partitioned between 5 N sodium hydroxide and diethyl ether. The organic phase was separated, washed sequentially with water and saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure to provide 27.1 gm (73%) of tetrahydropyran-2-yl 3-methoxyphenyl ether.

後処理

  1. temperaturewhile cooling in an ice/water bath
  2. washwashed sequentially with 100 mL 0.1 N sodium hydroxide and 100 mL saturated aqueous sodium chloride
  3. dry with materialThe remaining organic phase was dried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. distillationThe resulting oil was distilled
  6. distillationThe fraction distilling at 110-130° C.
  7. customwas collected
  8. custompartitioned between 5 N sodium hydroxide and diethyl ether
  9. customThe organic phase was separated
  10. washwashed sequentially with water and saturated aqueous sodium chloride
  11. dry with materialdried over magnesium sulfate
  12. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-045349d0d8964c5daa0fe1f9c20f1b05
出典データセット
uspto-grants-2005_04
特許番号
US06881733B1

反応ノート

読み込み中…