Ammonium Hydroxide → benzyl N-(2-sulfamoylethyl)carbamate
反応式
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][S:14](Cl)(=[O:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH4+:18].[OH-]>C(#N)C>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][S:14]([NH2:18])(=[O:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
Crude 2-(N-benzyloxycarbonylamino)ethanesulfonyl chloride was dissolved in acetonitrile (10 mL). The resulting solution was cooled on an ice/water bath and a solution 1:1 of 28% NH4OH (5 mL) and acetonitrile (5 mL) was dropped therein. After stirring for 30′, the solvents were evaporated off under vacuum and the crude residue was recrystallised with methanol to give 2-(N-benzyloxycarbonylamino)ethanesulfonamide as white powder (0.51 g; 1.96 mmol).
後処理
- temperatureThe resulting solution was cooled on an ice/water bath
- customwere evaporated off under vacuum
- customthe crude residue was recrystallised with methanol
出典と根拠
- ORDレコード
- ord-9151eec6f73942f585ec44fe0fb4f750
- 出典データセット
- uspto-grants-2005_04
- 特許番号
- US06881755B2
反応ノート
読み込み中…