Benzyl (S)-1-Methyl-2-(6-prop-2-ynyloxy-indazol-1-yl)-ethylcarbamate → Benzyl (S)-1-Methyl-2-(7H-pyrano[2,3-g]indazol-1-yl)-ethylcarbamate

HRID 1815972

反応式

HRID 1815972 の反応式
[CH3:1][C@H:2]([NH:17][C:18](=[O:27])[O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH2:14][C:15]#[CH:16])[CH:11]=2)[CH:6]=[N:5]1>C1(C)C=C(C)C=C(C)C=1>[CH3:1][C@H:2]([NH:17][C:18](=[O:27])[O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]3[O:13][CH2:14][CH:15]=[CH:16][C:11]3=2)[CH:6]=[N:5]1

参加物

3

反応物 1

HCID 86759654Benzyl (S)-1-Methyl-2-(6-prop-2-ynyloxy-indazol-1-yl)-ethylcarbamate

生成物 1

HCID 86759655Benzyl (S)-1-Methyl-2-(7H-pyrano[2,3-g]indazol-1-yl)-ethylcarbamate

試薬・触媒・溶媒 1

HCID 7947Mesitylene溶媒

実験手順

The product from Step B (2.37 g, 6.53 mmol) was heated in mesitylene (40 mL) in a manner similar to that described in Example 4, Step B to give, following purification (silica, 20% to 50% ethyl acetate in hexane), an oil (1.01 g, 43%): LC/MS (+APCI) m/z 364 (M+H).

後処理

  1. customto give
  2. custompurification (silica, 20% to 50% ethyl acetate in hexane)

出典と根拠

ORDレコード
ord-de72de7001b6469f9b08f168007a69b3
出典データセット
uspto-grants-2005_04
特許番号
US06881749B2

関連ノート

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