Potassium Carbonate → HCID 15510116、化合物

HRID 1816201ノート

反応式

HRID 1816201 の反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]([F:12])([CH3:11])[CH3:10])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:19]1([CH2:25][CH2:26][CH2:27][CH:28]([NH2:32])[CH:29]2[CH2:31][CH2:30]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(#N)C>[NH2:1][C:2]1[N:3]=[C:4]([C:9]([F:12])([CH3:11])[CH3:10])[N:5]=[C:6]([NH:32][CH:28]([CH:29]2[CH2:31][CH2:30]2)[CH2:27][CH2:26][CH2:25][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 114468284-Chloro-6-(2-Fluoropropan-2-Yl)-1,3,5-Triazin-2-AmineHCID 17958117α-Cyclopropylbenzenebutanamine

生成物 1

HCID 15510116HCID 15510116、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

1.52 g (0.008 mol) of 2-amino-4-chloro-6-(1-fluoro-1-methylethyl)-1,3,5-triazine and 1.64 g (0.012 mol) of potassium carbonate are introduced into 30 ml of acetonitrile. 1.50 g (0.008 mol) of 4-phenyl-1-cyclopropyl-1-butylamine, dissolved in 10 ml of acetonitrile, are added dropwise to this solution. The mixture is refluxed for three hours. The solid components are then filtered off with suction and the filtrate is evaporated on a rotary evaporator. The residue is purified by column chromatography (eluant: methyl acetate). This gives 2.36 g (86% of theory) of 2-amino-4-(1-fluoro-1-methylethyl)-6-(1-phenyl-4-cyclopropyl-4-butylamino)-1,3,5-triazine.

後処理

  1. additionare added dropwise to this solution
  2. temperatureThe mixture is refluxed for three hours
  3. filtrationThe solid components are then filtered off with suction
  4. customthe filtrate is evaporated on a rotary evaporator
  5. customThe residue is purified by column chromatography (eluant: methyl acetate)

出典と根拠

ORDレコード
ord-a7e79d39029f466e8e98e27f53e1c200
出典データセット
uspto-grants-2005_04
特許番号
US06884758B2

反応ノート

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