Pyrrolidine → HCID 22493345、化合物

反応式

[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.ClC1C=CC2C(=O)OC(=O)[NH:29]C=2C=1>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])=[C:2]([NH:1][CH2:18][C:17]2[NH:29][CH2:19][CH2:20][N:16]=2)[CH:7]=1

参加物

反応物 3

HCID 31268Pyrrolidine

HCID 3291054-Chloroisatoic anhydride

HCID 16776289HCID 16776289、化合物

生成物 1

HCID 22493345HCID 22493345、化合物

実験手順

(2-Amino-4-chlorophenyl)(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 7-chloro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give (4-chloro-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]phenyl}(1-pyrrolidinyl)methanone.