Pyrrolidine → {5-chloro-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]phenyl}(1-pyrrolidinyl)methanone
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.ClC1C=CC2[NH:30]C(=O)OC(=O)C=2C=1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][CH2:18][C:17]2[NH:30][CH2:19][CH2:20][N:16]=2)=[C:3]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])[CH:4]=1参加物
4
実験手順
{2-Amino-5-chlorophenyl}(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 6-chloro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give {5-chloro-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]phenyl}(1-pyrrolidinyl)methanone.