m-Chloroperbenzoic acid → HCID 69801129、化合物

HRID 1816591ノート

反応式

HRID 1816591 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([O:10]O)=[O:9])[CH:3]=1.[CH:12]([O:15][CH:16]([CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])([CH3:14])[CH3:13]>ClCCl.C(=O)([O-])O.[Na+]>[C:8]([O-:10])(=[O:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:2][CH2:3][CH2:4]/[CH:3]=[CH:2]\[CH2:7][CH2:6][CH2:27][CH2:28][CH2:23][CH2:22][CH2:16][CH3:17].[CH2:20]([O:19][C:17](=[O:18])[CH:16]([O:15][CH:12]([CH3:14])[CH3:13])[CH2:22][C:23]1[CH:24]=[CH:25][NH+:26]=[CH:27][CH:28]=1)[CH3:21]

参加物

5

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 22494133HCID 22494133、化合物

生成物 1

HCID 69801129HCID 69801129、化合物収率 119.8%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

6.0 g of m-chloroperbenzoic acid was added to a solution of 4.88 g ethyl 2-isopropoxy-3-(4-pyridyl)propanoate in dichloromethane (50 mL), followed by stirring at room temperature for 1.5 hours. After the reaction solution was diluted with saturated aqueous sodium hydrogencarbonate solution, the aqueous layer was extracted with dichloromethane for 3 times. The combined organic layer was dried over anhydrous sodium sulfate and then concentrated, to give 6.40 g crude 4-(3-ethoxy-2-isopropoxy-3-oxopropyl)-1-pyridinium oleate as a yellow oil.

後処理

  1. extractionthe aqueous layer was extracted with dichloromethane for 3 times
  2. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-32c0ad75e1a344c8abb11f739e7a6914
出典データセット
uspto-grants-2005_04
特許番号
US06884821B1

反応ノート

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