Sodium Hydroxide → 1-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

HRID 1816741ノート

反応式

HRID 1816741 の反応式
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][C:19]([O:28][CH3:29])([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:29][O:28][C:19]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:17][N:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[CH:15][CH:14]=2)[CH2:21][CH2:20]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 224947141-Acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

生成物 1

HCID 224946521-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine収率 97.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1-acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.5 g) and 10% NaOH aq. (10.2 ml) in ethyl alcohol (50 ml) was refluxed for 23.5 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with water, and dried to give 1-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.18 g).

後処理

  1. temperaturewas refluxed for 23.5 hours
  2. customThe reaction mixture was evaporated under reduced pressure
  3. washThe residue was washed with water
  4. customdried

出典と根拠

ORDレコード
ord-817354e23e2d4fe7b375eb987f56526b
出典データセット
uspto-grants-2005_04
特許番号
US06884868B1

反応ノート

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