Hydrochloric Acid → cis-2,6-Dimethyl-4-(4-piperazinylphenyl)morpholine

HRID 1816751ノート

反応式

HRID 1816751 の反応式
[CH3:1][C@H:2]1[O:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][N:18](C(=O)C)[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH2:3]1.Cl.[OH-].[Na+].ClCCl>C(O)C>[CH3:8][C@H:6]1[O:7][C@@H:2]([CH3:1])[CH2:3][N:4]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)=[CH:13][CH:14]=2)[CH2:5]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 540805081-[4-[4-(cis-2,6-Dimethylmorpholin-4-yl)phenyl]piperazin-1-yl]ethanone

生成物 1

HCID 69677628cis-2,6-Dimethyl-4-(4-piperazinylphenyl)morpholine収率 36.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture 1-[4-[4-(cis-2,6-dimethylmorpholin-4-yl)phenyl]piperazin-1-yl]ethanone (11.37 g) and 1.0 mol/l hydrochloric acid (225 ml) in ethanol (220 ml) was refluxed for 23 hours. The reaction mixture was added to a mixture of 1.0 mol/l sodium hydroxide solution and dichloromethane. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure to give cis-2,6-dimethyl-4-(4-piperazinylphenyl)morpholine (3.64 g).

後処理

  1. dry with materialdried over magnesium sulfate
  2. filtrationThe magnesium sulfate was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-32c120474e334b5f942fc3af8fca638a
出典データセット
uspto-grants-2005_04
特許番号
US06884868B1

反応ノート

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