Hydrochloric Acid → 5-hydroxy-5-methylhexan-2-one
反応式
[CH3:1][C:2]([OH:12])([CH2:4][CH2:5][C:6]1([CH3:11])OCC[O:7]1)[CH3:3].Cl.[OH-].[Na+]>CC(C)=O>[OH:12][C:2]([CH3:3])([CH3:1])[CH2:4][CH2:5][C:6](=[O:7])[CH3:11]参加物
5
実験手順
The obtained 2-methyl-4-(2-methyl[1,3]dioxolan-2-yl)butan-2-ol (21.18 g) was dissolved in acetone (165 ml). Thereafter, 1 M hydrochloric acid (6.6 ml) was added to the solution, and the obtained mixture was stirred at a room temperature for 2 hours. The reaction solution was neutralized with an aqueous 1 M sodium hydroxide solution. Thereafter, a saturated saline solution (100 ml) was added thereto, and acetone was then distilled off under a reduced pressure. After extraction with chloroform (200 ml×4), the organic layer was dried over anhydrous sodium sulfate. The solvent was then eliminated under a reduced pressure to obtain 5-hydroxy-5-methylhexan-2-one (14.23 g).
後処理
- distillationacetone was then distilled off under a reduced pressure
- extractionAfter extraction with chloroform (200 ml×4)
- dry with materialthe organic layer was dried over anhydrous sodium sulfate
出典と根拠
- ORDレコード
- ord-68f1967a99bd4f7289be026f4c8d9c7a
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07598244B2
反応ノート
読み込み中…