1-Butanol → 1-(Glycyloxy)butane chloride

HRID 1817299

反応式

HRID 1817299 の反応式
Cl.[NH2:2][CH2:3][C:4]([OH:6])=[O:5].S(Cl)([Cl:9])=O.[CH2:11](O)[CH2:12][CH2:13][CH3:14]>>[Cl-:9].[NH2:2][CH2:3][C:4]([O:6][CH2:11][CH2:12][CH2:13][CH3:14])=[O:5]

参加物

4

反応物 3

HCID 2631-ButanolHCID 22316Glycine HydrochlorideHCID 24386Thionyl Chloride

生成物 1

HCID 866139031-(Glycyloxy)butane chloride

反応条件

温度
70 °C

実験手順

To a suspension of glycine hydrochloride (10 g, 89.6 mmol) in 250 mL butanol under nitrogen was added thionyl chloride (45.7 mL, 627 mmol) dropwise. After the addition was complete, the solution was heated at 70° C. overnight. The volatile components were removed on the roto-evaporator and the residue was suspended and evaporated from toluene three times. The resulting crude gum was dissolved in an equal weight of toluene for easy transfer and was used as is in the next reaction.

後処理

  1. additionAfter the addition
  2. customThe volatile components were removed on the roto-evaporator
  3. customevaporated from toluene three times
  4. dissolutionThe resulting crude gum was dissolved in an equal weight of toluene for easy transfer
  5. customas is in the next reaction

出典と根拠

ORDレコード
ord-491dd942da334ab9a9e0643ea6bc3180
出典データセット
uspto-grants-2009_10
特許番号
US07598264B2

関連ノート

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