関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 4-Propylanisole | HCID 7702 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(2-Methoxy-5-propylphenyl)ethanone | HCID 68454475 | — |
反応手順
A suspension of 10.6 g of AlCl3 in 150 mL of dichloromethane is cooled to −10° C. 5.7 mL of AcCl and 6 g of 4-propylanisole are added. The medium is stirred for 30 minutes at −10° C. and then poured into a beaker containing ice mixed with 35% HCl. After separation of the phases by settling, the aqueous phase is extracted 3 times with DCM and the combined organic phases are washed with water, with saturated NaCl solution, dried over MgSO4 and then evaporated to give 7.86 g of a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07598392B2 |
|---|
| 出典データセット | uspto-grants-2009_10 |
|---|
| ORD ID | ord-d2998c6f826c4f83a989bb45635e8b74 |
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| 出典メモ | uspto-grants-2009_10 |
|---|
