反应详情

温度

-10 °C

A suspension of 10.6 g of AlCl3 in 150 mL of dichloromethane is cooled to −10° C. 5.7 mL of AcCl and 6 g of 4-propylanisole are added. The medium is stirred for 30 minutes at −10° C. and then poured into a beaker containing ice mixed with 35% HCl. After separation of the phases by settling, the aqueous phase is extracted 3 times with DCM and the combined organic phases are washed with water, with saturated NaCl solution, dried over MgSO4 and then evaporated to give 7.86 g of a brown oil.

1. additionpoured into a beaker
2. additioncontaining ice
3. customAfter separation of the phases
4. extractionthe aqueous phase is extracted 3 times with DCM
5. washthe combined organic phases are washed with water, with saturated NaCl solution
6. dry with materialdried over MgSO4
7. customevaporated