Diisopropylethylamine → 4-Bromo-2-nitro-N-[2-(trifluoromethoxy)ethyl]aniline

反応式

Cl.[F:2][C:3]([F:9])([F:8])[O:4][CH2:5][CH2:6][NH2:7].[Br:10][C:11]1[CH:16]=[CH:15][C:14](F)=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=1.C(N(CC)C(C)C)(C)C>>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([NH:7][CH2:6][CH2:5][O:4][C:3]([F:9])([F:8])[F:2])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=1

参加物

反応物 3

HCID 81531Diisopropylethylamine

HCID 27363284-Bromo-1-fluoro-2-nitrobenzene

HCID 448908072-(Trifluoromethoxy)ethan-1-amine hydrochloride

生成物 1

HCID 688735474-Bromo-2-nitro-N-[2-(trifluoromethoxy)ethyl]aniline

実験手順

The title compound was prepared according to the procedure described in Step A of Example 5 from 2-(trifluoromethoxy)ethanamine hydrochloride (J. Org. Chem. 2001, 66, 1061-1063), 4-bromo-1-fluoro-2-nitrobenzene (Wako Pure Chemical Industries, Ltd.) and N,N-diisopropylethylamine.

出典と根拠

ORDレコード: ord-31d950ee22ec4e3dafaf373ea9ded853
出典データセット: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07598393B2

反応ノート

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