Trimethyl((2-nitrophenyl)ethynyl)silane → HCID 57883359、化合物
反応式
[CH3:1][Si:2]([CH3:15])([CH3:14])[C:3]#[C:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-])=O>CO.[Pd]>[CH3:14][Si:2]([CH3:1])([CH3:15])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11]参加物
4
実験手順
10.9 g (50 mmol) of trimethyl-(2-nitrophenylethynyl)silane were dissolved in 200 ml of methanol, and 0.5 g of palladium-on-carbon (5%) were added. The mixture was then hydrogenated in an autoclave at 4 bar for 12 h. Removal of the solvent and column-chromatographic purification on silica gel 60 (mobile phase: methylene chloride) gave 4.1 g of 2-(2-trimethylsilylethyl)phenylamine [log P (pH 2.3)=2.58].
後処理
- customRemoval of the solvent and column-chromatographic purification on silica gel 60 (mobile phase: methylene chloride)
出典と根拠
- ORDレコード
- ord-d1119feb7f484e87805b6e04cb9b5057
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07598389B2
反応ノート
読み込み中…