Piperidine → (E,E)-2-(Benzylaminocarbonyl)-3-(4-hydroxy-3-methoxystyryl)acrylonitrile

HRID 1818045

反応式

HRID 1818045 の反応式
N1CCCCC1.[OH:7][C:8]1[CH:17]=[CH:16][C:11]([CH:12]=[CH:13][CH:14]=O)=[CH:10][C:9]=1[O:18][CH3:19].[C:20]([CH2:22][C:23]([N-:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])#[N:21]>C(O)C>[CH2:26]([NH:25][C:23](/[C:22](=[CH:14]/[CH:13]=[CH:12]/[C:11]1[CH:16]=[CH:17][C:8]([OH:7])=[C:9]([O:18][CH3:19])[CH:10]=1)/[C:20]#[N:21])=[O:24])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

5

反応物 3

HCID 8082PiperidineHCID 99842-Propenal, 3-(4-hydroxy-3-methoxyphenyl)-HCID 178511179N-(cyanoacetyl)benzylamide

生成物 1

HCID 11522842(E,E)-2-(Benzylaminocarbonyl)-3-(4-hydroxy-3-methoxystyryl)acrylonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The compound was prepared as described in Example 37 by adding piperidine to a solution of 4-hydroxy-3-methoxycinnamaldehyde (35 mg, 0.2 mmol) and N-(cyanoacetyl)benzylamide (34 mg, 0.2 mmol) in ethanol. After recrystallization from ethanol-water a yellow solid was obtained (50 mg, 75%). The product gave the following analytical data:

後処理

  1. customThe compound was prepared
  2. customAfter recrystallization from ethanol-water a yellow solid
  3. customwas obtained (50 mg, 75%)
  4. customThe product gave the following analytical data

出典と根拠

ORDレコード
ord-1076ebe740ce40c7a1d72d72c5535048
出典データセット
uspto-grants-2009_10
特許番号
US07598419B2

関連ノート

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