Sodium Carbonate → 3-Benzyl-7-bromo-5-methyl-benzofuran

温度

80 °C

1-Bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene (10.86 g, 25 mmol), tetrabutylammonium chloride (7.65 gm, 27.5 mmol), sodium carbonate (6.62 g, 62.46 mmol), sodium formate (1.7 g, 25 mmol), and bis(acetonitrile)dichloropalladium(II) (0.467 g, 1.8 mmol) was added to 50 ml DMF. The mixture was degassed and heated under nitrogen at 80° C. for 105 minutes, then cooled to room temperature. Water was added and the mixture was extracted with a hexanes/ethyl acetate (1:1) mixture. The solution was dried onto 20 gm silica gel, the silica gel was layered over 100 gm silica gel in a fritted funnel and eluted with four 400 ml portions of hexanes. The hexanes was removed under reduced pressure to give 3-benzyl-7-bromo-5-methyl-benzofuran (3.97 g, 52% yield). MS: (M+H)+ 302.

1. customThe mixture was degassed
2. temperaturecooled to room temperature
3. additionWater was added
4. extractionthe mixture was extracted with a hexanes/ethyl acetate (1:1) mixture
5. customThe solution was dried onto 20 gm silica gel
6. customthe silica gel was layered over 100 gm silica gel in a fritted funnel
7. washeluted with four 400 ml portions of hexanes
8. customThe hexanes was removed under reduced pressure

ORDレコード

ord-7ac7c6a36b2d43f6bce03c300bbc3b33

出典データセット

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07741326B2