3-Methoxypropylamine → (7-Bromo-3-nitroquinolin-4-yl)-(3-methoxypropyl)amine

反応式

[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:16][O:17][CH2:18][CH2:19][CH2:20][NH2:21]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:21][CH2:20][CH2:19][CH2:18][O:17][CH3:16])=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 16723-Methoxypropylamine

HCID 219843617-Bromo-4-chloro-3-nitroquinoline

生成物 1

HCID 21984327(7-Bromo-3-nitroquinolin-4-yl)-(3-methoxypropyl)amine収率 94.2%

実験手順

7-Bromo-4-chloro-3-nitroquinoline (29.54 g, 102.7 mmol) was reacted with 3-methoxy propyl amine (10.07 g, 113.0 mmol) according to the method described in Part A of Examples 125-135 to provide 32.9 g of (7-bromo-3-nitroquinolin-4-yl)-(3-methoxypropyl)amine as a yellow solid. The product was not recrystallized.

出典と根拠

ORDレコード: ord-0577e3a026534b0f825b9a02214d4dce
出典データセット: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07598382B2

反応ノート

読み込み中…

参加物