Hydrochloric Acid → 2-(Methanesulfonyl)benzylamine hydrochloride
反応式
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([CH3:18])(=[O:17])=[O:16])(C)(C)C.[ClH:20]>O1CCOCC1.C(Cl)(Cl)Cl>[ClH:20].[CH3:18][S:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:8][NH2:7])(=[O:16])=[O:17]参加物
5
実験手順
(2-Methanesulfonyl-benzyl)-carbamic acid tert-butyl ester (1.55 g, 5.43 mmol) was dissolved in warm dioxane (50 mL) and cooled to room temperature. HCl solution (4M solution in dioxane, 20 ml, 80 mmol) was added. After 20 h, a white precipitate had formed. The reaction was diluted with CHCl3 (50 mL) and filtered. The white solid was washed with CHCl3 and dried in-vacuo to yield 1.075g of 2-methanesulfonyl-benzylamine hydrochloride as an off white solid, m/z 186.6 (M+1)+.
後処理
- customa white precipitate had formed
- filtrationfiltered
- washThe white solid was washed with CHCl3
- customdried in-vacuo
出典と根拠
- ORDレコード
- ord-9a10e61025534704825a2a2dc82d2516
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07601714B2
反応ノート
読み込み中…