Water → Tert-butyl 3-(2-isopropylphenoxy)propionate

HRID 1819503ノート

反応式

HRID 1819503 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].C(OC(C)(C)C)(C)(C)C.[K].O.[C:22]([O:26][C:27](=[O:30])[CH:28]=[CH2:29])([CH3:25])([CH3:24])[CH3:23]>>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:29][CH2:28][C:27]([O:26][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:30])([CH3:3])[CH3:2]

参加物

5

反応物 4

HCID 962WaterHCID 69432-IsopropylphenolHCID 15458tert-Butyl acrylateHCID 86607002Potassium tert-butyloxide

生成物 1

HCID 23119473Tert-butyl 3-(2-isopropylphenoxy)propionate収率 36.9%

反応条件

温度
130 °C

実験手順

2-Isopropylphenol (6 g) was dissolved in acrylic acid tert-butyl ester (6.2 g), and to the mixture was added potassium tert-butyloxide (0.3 g). The reaction mixture was stirred at 130° C. for 6 h. To the reaction mixture was added water, the reaction mixture extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated. The obtained residue was purified by column chromatography (hexane:ethyl acetate=9:1) to obtain the compound (10) 4.3 g.

後処理

  1. extractionthe reaction mixture extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe obtained residue was purified by column chromatography (hexane:ethyl acetate=9:1)

出典と根拠

ORDレコード
ord-f08906a112a2445eb2d6592526fe52b8
出典データセット
uspto-grants-2009_10
特許番号
US07601746B2

反応ノート

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