Hydrochloric Acid → 2,6-Dimethyl-4-nitroaniline

HRID 1820117ノート

反応式

HRID 1820117 の反応式
Cl.[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([CH3:12])[C:4]=1[NH:13]C(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>O>[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([CH3:12])[C:4]=1[NH2:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 50851089N-(2,6-dimethyl-4-nitrophenyl)acetamide

生成物 1

HCID 281592,6-Dimethyl-4-nitroaniline収率 97.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
140 °C

実験手順

Concentrated hydrochloric acid (17.5 mL) was added to N-(2,6-dimethyl-4-nitro-phenyl)-acetamide (5.05 g) and heated to 140° C. for 30 minutes in a sealed microwave process vial. The reaction mixture was neutralized with solid sodium carbonate in water and the precipitated product was collected by filtration and washed with water (100 mL) to furnish 3.93 g (97% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 2.15 (s, 6H), 6.15 (b, 2H), 7.79 (s, 2H).

後処理

  1. filtrationthe precipitated product was collected by filtration
  2. washwashed with water (100 mL)

出典と根拠

ORDレコード
ord-6495e0fce7c44ab6b87b955008f683f2
出典データセット
uspto-grants-2009_10
特許番号
US07601870B2

反応ノート

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