Water → 2-Cyclopentyl-N-(2,6-dimethyl-4-nitro-phenyl)-acetamide

HRID 1820118

反応式

HRID 1820118 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([CH3:11])[C:3]=1[NH2:12].[CH:13]1([CH2:18][C:19](Cl)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14]1.O>C(#N)C>[CH:13]1([CH2:18][C:19]([NH:12][C:3]2[C:2]([CH3:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[CH:5][C:4]=2[CH3:11])=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14]1

参加物

5

反応物 3

HCID 962WaterHCID 281592,6-Dimethyl-4-nitroanilineHCID 3485182Cyclopentylacetyl chloride

生成物 1

HCID 687127672-Cyclopentyl-N-(2,6-dimethyl-4-nitro-phenyl)-acetamide収率 89%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
150 °C

実験手順

2,6-Dimethyl-4-nitro-phenylamine (0.98 g) and cyclopentylacetyl chloride (0.99 mL) were dissolved in acetonitrile (10 mL) and heated to 150° C. for 5 minutes in a sealed microwave process vial. Water (10 mL) was added to the reaction mixture, and the product was collected by filtration and washed with water (20 mL) and heptane (20 mL) to furnish 1.45 g (89% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 1.24 (m, 2H), 1.54 (m, 2H), 1.63 (m, 2H), 1.79 (m, 2H), 2.25 (s, 6H), 2.27 (m, 1H), 2.36 (d, 2H), 7.98 (s, 2H), 9.56 (s, 1H).

後処理

  1. filtrationthe product was collected by filtration
  2. washwashed with water (20 mL) and heptane (20 mL)

出典と根拠

ORDレコード
ord-4a398c3554bb4df49a1d0c78a5959536
出典データセット
uspto-grants-2009_10
特許番号
US07601870B2

関連ノート

読み込み中…