反応式
C1(S(N2C3C(=CC=CC=3)C(Br)=C2)(=O)=O)C=CC=CC=1.COC1C=C(B(O)O)C=CC=1OC.[CH3:33][C:34]1[CH:35]=[N:36][C:37]2[C:42]([CH:43]=1)=[CH:41][CH:40]=[CH:39][C:38]=2[S:44](Cl)(=[O:46])=[O:45].C1(S([N:57]2[C:65]3[C:60](=[CH:61][C:62]([Cl:66])=[CH:63][CH:64]=3)[C:59](Br)=[CH:58]2)(=O)=O)C=CC=CC=1.[CH:68]1([O:73][C:74]2[CH:75]=[C:76](B(O)O)[CH:77]=[CH:78][C:79]=2[O:80][CH3:81])[CH2:72][CH2:71][CH2:70][CH2:69]1>>[Cl:66][C:62]1[CH:61]=[C:60]2[C:65](=[CH:64][CH:63]=1)[N:57]([S:44]([C:38]1[CH:39]=[CH:40][CH:41]=[C:42]3[C:37]=1[N:36]=[CH:35][C:34]([CH3:33])=[CH:43]3)(=[O:46])=[O:45])[CH:58]=[C:59]2[C:76]1[CH:77]=[CH:78][C:79]([O:80][CH3:81])=[C:74]([O:73][CH:68]2[CH2:69][CH2:70][CH2:71][CH2:72]2)[CH:75]=1参加物
6
反応物 5
生成物 1
実験手順
8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline 95 was prepared using the same protocol as described in Examples 21 and 22, substituting 8-quinoline-sulfonyl chloride, 1-Benzenesulfonyl-3-bromoindole and 3,4-dimethoxyphenyl boronic acid with 3-methyl-quinoline-8-sulfonyl chloride, 1-Benzenesulfonyl-3-bromo-5-chloro-indole and 3-cyclopentyloxy-4-methoxy-phenylboronic acid respectively. MS(ESI) [M+H+]+=547.10.
出典と根拠
- ORDレコード
- ord-40cee7d49bd44894b607fadfab00dc04
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07605168B2
関連ノート
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