Pyrrolidine → 4-[1-(1-methylethyl)-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-2-[4-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine

反応式

[CH3:1][CH:2]([N:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]3[N:15]([S:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)(=[O:28])=[O:27])[C:16]([C:18]4[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=4)=[CH:17][C:10]=23)[C:6]([C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=2)=[N:5]1)[CH3:3].[NH:44]1[CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH3:3][CH:2]([N:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]3[N:15]([S:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)(=[O:28])=[O:27])[C:16]([C:18]4[CH:25]=[CH:24][C:21]([CH2:22][N:44]5[CH2:48][CH2:47][CH2:46][CH2:45]5)=[CH:20][CH:19]=4)=[CH:17][C:10]=23)[C:6]([C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=2)=[N:5]1)[CH3:1]

参加物

反応物 2

HCID 31268Pyrrolidine

HCID 866133284-[4-[1-(1-methylethyl)-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]benzaldehyde

生成物 1

HCID 690015254-[1-(1-methylethyl)-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-2-[4-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine

実験手順

Following the procedure described for Intermediate 101 using 4-[4-[1-(1-methylethyl)-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]benzaldehyde and pyrrolidine provided the title compound. ESMS [M+H]+=647.6.

出典と根拠

ORDレコード: ord-74103ccea2e041ed9671511a6ac6865b
出典データセット: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07605266B2

反応ノート

読み込み中…