Hydrochloric Acid → (E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetic acid

HRID 1821434ノート

反応式

HRID 1821434 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]2[CH:23]=[CH:22][C:15]([O:16][CH2:17][C:18]([O:20]C)=[O:19])=[C:14]([O:24][CH3:25])[C:13]=2[N+:26]([O-:28])=[O:27])=[N:2]1.[OH-].[Na+].Cl>CO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]2[CH:23]=[CH:22][C:15]([O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:14]([O:24][CH3:25])[C:13]=2[N+:26]([O-:28])=[O:27])=[N:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86628222methyl (E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetate

生成物 1

HCID 68997069(E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetic acid収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

A solution of methyl (E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetate obtained in Step 2 in methanol (20 mL) was added with 2 mol/L aqueous sodium hydroxide solution (10 mL) and stirred at 60° C. for 1 hour. To the reaction mixture under ice-cooling, 2 mol/L hydrochloric acid was added to neutralize the mixture. The precipitated solid was collected by filtration to obtain (E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetic acid (1.9 g, 100%).

後処理

  1. temperatureTo the reaction mixture under ice-cooling
  2. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-e85f4a63183042278d4e645fda456139
出典データセット
uspto-grants-2009_10
特許番号
US07605272B2

反応ノート

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