Triethylamine → 5-Ethylpyrazin-2-amine
反応式
[C:1]([C:3]1[N:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1)#[CH:2].C(N(CC)CC)C>C(OCC)(=O)C.[OH-].[OH-].[Pd+2]>[NH2:9][C:6]1[CH:5]=[N:4][C:3]([CH2:1][CH3:2])=[CH:8][N:7]=1参加物
5
実験手順
To a stirred solution of 5-ethynyl-2-aminopyrazine (18 mg; 0.151 mmol), in ethyl acetate (500 μL) was added triethylamine (63 μL; 0.45 mmol) and Pd(OH)2 (0.01 mmol; 20% wt on carbon). The reaction was placed under a hydrogen atmosphere at 45 psi and shook for 6 hours. The reaction was filtered and concentrated under reduced pressure to yield an off white solid (84% yield).
後処理
- filtrationThe reaction was filtered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-3fdbf0d17dad46aab2b0a2f5baa7b9a0
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07608618B2
反応ノート
読み込み中…