Sodium Hydroxide → phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone

HRID 1821841ノート

反応式

HRID 1821841 の反応式
[C:1]1([C:7]([C:9]2[N:17](S(C3C=CC=CC=3)(=O)=O)[C:12]3=[CH:13][N:14]=[CH:15][CH:16]=[C:11]3[CH:10]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CCO>[C:1]1([C:7]([C:9]2[NH:17][C:12]3=[CH:13][N:14]=[CH:15][CH:16]=[C:11]3[CH:10]=2)=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 689825291h-Pyrrolo[2,3-c]pyridine,2-benzoyl-1-(phenylsulfonyl)-

生成物 1

HCID 57893467phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone収率 84.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Phenyl[1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methanone (Reference Example 13) (2.2 g, 6.1 mmol) and 10% aq NaOH (70 mL) in EtOH (135 mL) was heated to reflux. After 14 h, the mixture was concentrated under reduced pressure to remove most of the EtOH. The mixture was diluted with H2O (50 mL) and extracted with EtOAc (2×100 mL). The combined extracts were washed with saturated NaCl (25 mL), dried (Na2SO4) and concentrated under reduced pressure. Trituration in EtOAc/diethyl ether gave phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone (1.14 g, 83%).

後処理

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customto remove most of the EtOH
  3. additionThe mixture was diluted with H2O (50 mL)
  4. extractionextracted with EtOAc (2×100 mL)
  5. washThe combined extracts were washed with saturated NaCl (25 mL)
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-eaaedbffbc1f4e0c9d736fc0419a3cf8
出典データセット
uspto-grants-2009_10
特許番号
US07608627B2

反応ノート

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